Many insects use milkweed blossoms. Native bees and wasps, butterflies and moths all feast on the nutritious nectar.
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You may be aware that Monarch butterflies depend on milkweed as a larval host. That is, the adults lay eggs on milkweed leaves, and when the eggs hatch, caterpillars eat the leaves.
There's a nice overview on the Monarch Watch site.
Monarchs have evolved a way to deal with the specialized chemicals that milkweeds produce, and may use it to reduce the effects of a parasite (Ophryocystis elektroscirrha).
Many other species have evolved tolerance, including a specialized food chain of aphids, crab spiders, and pampilid wasps. Here's a milkweed beetle.
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